SCI
18September
PulmonaryIllnessRelatedtoE-CigaretteUseinIllinoisandWisconsin—PreliminaryReport
LaydenJE,GhinaiI,PrayI,etal.PulmonaryIllnessRelatedtoE-CigaretteUseinIllinoisandWisconsin-PreliminaryReport.NEnglJMed.
AddressreprintrequeststoDr.LaydenattheIllinoisDe-partmentofPublicHealth,69W.Wash-ingtonSt.,Chicago,IL,oratjennifer.layden
illinois.gov.BACKGROUND背景
E-cigarettesarebattery-operateddevicesthatheataliquidanddeliveranaerosolizedproducttotheuser.Pulmonaryillnessesrelatedtoe-cigaretteusehavebeenreported,aerosolizebutnolargeserieshasbeendescribed.InJuly,theWisconsinDepartmentofHealthServicesandtheIllinoisDepartmentofPublicHealthreceivedreportsofpulmonarydiseaseassociatedwiththeuseofe-cigarettes(alsocalledvaping)andlaunchedacoordinatedpublichealthinvestigation.
电子烟是电池供电装置,其加热液体并将雾化产物输送给使用者。与电子烟使用相关的肺部疾病已有报道,但尚无大宗描述。年7月,威斯康辛州卫生服务部(WisconsinDepartmentofHealthServices)和伊利诺伊州公共卫生部(IllinoisDepartmentofPublicHealth)获得了与使用电子烟(也称vaping)有关的肺部疾病的报告,并协作展开了一项公共卫生调查。
METHODS方法
Wedefinedcasepatientsaspersonswhoreporteduseofe-cigarettedevicesandrelatedproductsinthe90daysbeforesymptomonsetandhadpulmonaryinfiltratesonimagingandwhoseillnesseswerenotattributedtoothercauses.Medicalrecordabstractionandcasepatientinterviewswereconductedwiththeuseofstandardizedtools.
我们将病例患者定义为在症状出现前90天内报告使用电子烟设备和相关产品,影像学上有肺部浸润,且疾病不是由其他原因引起的人。使用标准化工具进行病历提取和患者随访。
RESULTS结果
Therewere53casepatients,83%ofwhomweremale;themedianageofthepatientswas19years.Themajorityofpatientspresentedwithrespiratorysymptoms(98%),gastrointestinalsymptoms(81%),andconstitutionalsymptoms(%).Allcasepatientshadbilateralinfiltratesonchestimaging(whichwaspartofthecasedefinition).Atotalof94%ofthepatientswerehospitalized,32%underwentintubationandmechanicalventilation,andonedeathwasreported.Atotalof84%ofthepatientsreportedhavingusedtetrahydrocannabinolproductsine-cigarettedevices,althoughawidevarietyofproductsanddeviceswasreported.SyndromicsurveillancedatafromIllinoisshowedthatthemeanmonthlyrateofvisitsrelatedtosevererespiratoryillnessinJunethroughAugustofwastwicetheratethatwasobservedinthesamemonthsin.
患者53例,男性占83%;患者的平均年龄为19岁。绝大多数患者表现为呼吸系统症状(98%)、胃肠道症状(81%)和全身症状(%)。所有病例均有胸部影像学双侧浸润(这是病例定义的一部分)。共有94%的患者住院,32%的患者接受了插管和机械通气,并有一例死亡报告。共有84%的患者报告曾在电子烟设备中使用四氢大麻酚产品,当然其他报告的产品和设备种类也很多。来自伊利诺伊州的症状监测数据显示,年6月至8月,与严重呼吸系统疾病相关的月平均访视率是年同期的两倍。
CONCLUSIONS结论
Casepatientspresentedwithsimilarclinicalcharacteristics.Althoughthefeaturesofe-cigaretteusethatwereresponsibleforinjuryhavenotbeenidentified,thisclusterofillnessesrepresentsanemergingclinicalsyndromeorsyndromes.Additionalworkisneededtocharacterizethepathophysiologyandtoidentifythedefinitivecauses.
患者临床表现相似。虽然电子烟的使用危害的特征尚未确定,但这类疾病代表了一种或多种临床症状的出现。还需要进行更多的工作,以确定病理生理学特征和确定明确的原因。
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